The low-down on LDN.
Low-dose Naltrexone (LDN) is a safe alternative treatment for several chronic neurologic, Rheumatologic, psychiatric, and gastrointestinal inflammatory conditions.
In low doses - typically 1.5 mg to 5 mg - it operates uniquely as an anti-inflammatory agent in the central nervous system by acting on microglial cells.
An ever-growing body of research is demonstrating that LDN significantly relieves pain, fatigue, cognitive impairment and other symptoms of several different chronic inflammatory conditions including fibromyalgia, ME/CFS and other neuropathic pain.
#1. Naltrexone Reduces Insulin Resistance
Studies have shown that using Naltrexone helps to lower fasting insulin levels by up to 40%. This can help with weight management as weight gain in many people (especially hypothyroid patients) is linked to insulin resistance.
Naltrexone modulates cellular resistance to insulin (decreased insulin resistance), and since insulin resistance plays a direct role in high testosterone levels in females – LDN can have multiple benefits in this particular patient group.
#2. Naltrexone Can Increase Growth Hormone in Certain patients
Studies have shown that Naltrexone may help to increase Growth hormone levels. This is important because growth hormone helps to build and maintain lean muscle mass. LDN helps to decrease insulin levels which can improve growth hormone levels.
#3. Naltrexone Modulates Appetite
If your body is burning 2,000 calories per day your brain will send signals to the body to help you consume as close to 2,000 calories per day. If you only consume 1,500 calories, your brain will tell you that you are hungry. Naltrexone can help to "normalise" this mismatch between calories burned and appetite.
#4. Naltrexone Acts as an Anti-Inflammatory Agent
LDN helps to reduce inflammation and studies have shown that it can be used as a novel anti-inflammatory agent. As you probably know inflammation is involved in the pathophysiology of many diseases and disease states including fibromyalgia, arthritis and chronic nerve pain.
#5. Naltrexone May Help Improve Sleep & Sleeping Patterns
Lack of sleep leads to inflammation, adrenal stress and weight gain. Naltrexone has been shown to help improve sleeping patterns significantly in patients with sleep apnoea. Naltrexone can be used to help improve sleeping patterns in individuals with chronic pain, sleep apnoea, hypothyroidism and Hashimoto's.
#6. Naltrexone & Thyroid Function (Including Hashimoto's Thyroiditis)
Studies have shown that Naltrexone can help to increase total T3 levels and improve T4 to T3 conversion. In addition, LDN can help to improve the immune system and reduce autoantibodies in some autoimmune conditions.
So, what does this all mean?
Naltrexone is a little-known medication that can help certain patients lose weight by modulating certain hormone imbalances, improving/normalising hypothalamic function, improving sleep, improving thyroid production/conversion and potentially reducing inflammatory levels.
Elixir compounds Naltrexone in low doses between of 0.5-4.5mg in both capsule and liquid form.
For more information, contact Elixir Compounding today!