There’s a direct connection between histamines, Fibro and chronic fatigue syndrome. Overactive Mast Cells (the underlying cause of Fibro pain) drive high levels of histamine which often drive symptoms including allergies and sensitivity to pollen.
We know that Mast Cell Activation (MSA) can cause postural orthostatic tachycardia syndrome (POTS). MCA causes orthostatic intolerance, particularly in sufferers who experience ‘flushing’. In addition to flushing, sufferers often experience shortness of breath, headache, skin rashes, light-headedness, excessive urination, and gastrointestinal symptoms (including vomiting). Histamines and MSA play a significant role in a subset of sufferers with Fibro, ME/CFS and POTS.
Histamines – A Quick Overview:
Histamine is a potent signalling molecule or biogenic amine made from the amino acid histidine. It is naturally found in plants and animals. Histamine helps regulate many bodily functions including digestion, sleep, sexual function, and blood pressure, and in the brain, it functions as a neurotransmitter, carrying chemical messages between nerve cells.
Under normal circumstances small amounts of histamine help to facilitate health and balance in many systems of the body. In response to foreign pathogens, wounds and allergies, however, large quantities of histamine are released in our bodies by Mast Cells and Basophils - two types of white blood cells that reside in blood and tissues respectively. Those with allergies often take antihistamine medications to provide relief of symptoms associated with this inflammatory response.
Histamine exerts its effects by binding to four different receptor sites on cells. Each site is able to produce different symptoms by impacting different tissues and organ systems.
Putting a Halt to the Histamine Hell:
Because Fibro pain is driven by MSA, many sufferers also suffer the side effects caused by excessive histamines. Thankfully, there is a way to reduce MSA and histamine activity – Palmitoylethanolamide (PEA). PEA works by ‘binding’ to, and de-activating overactive mast cells.
Because PEA is targeting the root cause of the pain problem, the very immune cells that make the
hyper-excitable in the first place this allows PEA to act more as a disease modifying agent rather than a symptom modifying agent.
So, if you’ve got a rowdy party full of Fibro pain and histamine hell going on in your body, contact Elixir Compounding today. We offer complementary face-to-face or phone consultations where we can discuss your individual symptoms and recommend a treatment protocol to get your party under control.