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Mitochondrial Dysfunction, and Autophagy in Fibromyalgia

In the pathophysiology of fibromyalgia neuroendocrine factors, anomalies of the autonomous nervous system, genetic characteristics, and environmental and psychosocial factors are implicated. Alterations to the cells of the central nervous system that are present in fibromyalgia are due to the toxic effects of free radicals by the high concentrations of polyunsaturated fatty acids of the membranes that are easily oxidised and the low level of protective antioxidant enzymes.

In Fibro, defects are produced in any part of the cycle in the generation of adenosine-5′-triphosphate (ATP) by the mitochondria, which can dramatically compromise energy production. The degradation of the mitochondria dependent on autophagy or mitophagy is an important process for maintaining the critical integrity of the mitochondria and limiting the production of reactive oxygen species (ROS). Therefore, the deregulation of autophagy and mitochondrial dysfunction represents key aspects in the pathophysiology of Fibro.

Management with antioxidants including Nicotinamide Adenine Dinucleotide (NADH), Coenzyme Q10 (CoQ10), N-Acetyl-Cysteine (NAC) and even melatonin dramatically improve mitochondrial function and reduce adrenal fatigue.

If you’re fighting Fibro and suffer from Fibro fatigue, contact Elixir today. We specialise in treating this cruel and debilitating condition and provide advice and information treating this debilitating condition. We develop patient-centred treatment protocols based largely on advanced nutrient therapies. We offer complementary phone consultations where we assess symptoms and recommend an individualised treatment protocol. So, if you or someone you know is fighting Fibro, contact Elixir today.

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